土-结构相互作用体系合成模态阻尼比的振动台模型试验研究

本文籍振动台模型试验。研究了SSI体系的合成模态阻尼比问题。文中首先阐明了在SSI体系直接动力分析中应采用合成模态阻尼比的观点。研究了合成模态阻尼纟的实测确定方法。并在不同工况下，通过对模型不同部位测点的传递函数，基本频率，基本合成模态阻尼比等实测数据考虑，验证了SSI体系合成模态的存在性，合成模态阻尼比与相同应变下不考虑相互作用的单纯地基土体或刚性地基结构阻尼比的差异性及其在递增动力作用下的变化规律。     

高g值冲击下存储测试电路模块缓冲保护研究

为了采用弹载存储测试技术记录弹体高速侵彻硬目标过程中的加速度—时间曲线,必须对存储测试电路模块进行缓冲保护。本文利用非线性缓冲理论、技术,选择较理想的缓冲材料,设计出缓冲器件-泡沫铝试件,进行了静态压缩,得到应力-应变曲线,采用LS-DYNA模拟了空气炮冲击实验中泡沫铝试件的缓冲效果,并对应用于某型号弹侵彻混凝土靶的存储测试电路模块进行了缓冲保护,提高了数据的捕获率和电路模块的重复使用次数。通过试验证明了所设计缓冲器件对电路模块具有保护效果。     

机载导弹惯性制导装置生产测试工艺研究

从机载导弹惯性制导装置的工厂生产测试的实际情况出发，提出了使用自由方位惯性坐标系作为静止导航测试中的导航参考坐标系，证明了它和以发射点地理坐标系为基础的惯性坐标系的等效性，论证了测试平台所需的调平精度，给出了确定测试指标的算法。这种方法的应用，可节省测试场地的建设经费，提高生产效率。     

一种用于金属薄板轴向拉压疲劳试验的防弯夹具

在金属薄板的轴向疲劳S-N曲线测试中,研究将一种侧向防弯曲夹具应用于存在压向载荷的试验。通过粘贴应变片方法测量试样的表面应力,对试样的受力情况做了定量的分析。测量结果表明试样安装防弯曲夹具后,基本消除了由压缩失稳产生的弯曲应力。且通过对不同拧紧方式的测量,表明一定的夹紧力下不对试验力产生影响。试验夹具设计成对试样中心轴线的支撑而让边缘疲劳敏感部位处在非接触状态,试样断口表明疲劳起源在这些并没有与试样接解的部位。用钛和铝两种材料的薄板在不同试验机上进行了不同寿命和频率的试验,试验结果与正应力比试验同时给出以对比,各种研究表明本试验有效解决了薄板疲劳受压时的失稳问题。     

高耸异型烟囱结构风压和风振系数试验研究

本文在模拟的大气边界层中,对某一发电厂高耸异型烟囱的刚性模型进行了测压试验研究,得到了这一结构的平均风压系数、最大和最小风压系数分布,以及该结构的风荷载体型系数;结果表明在烟囱外形明显变化的局部区域,风压绝对值较大,与理论分析一致。同时,对动态测力试验模型进行了高频动态天平测力试验研究,详细介绍了试验及数据处理方法,根据试验结果计算得到了该烟囱在风作用下的动力响应和风振系数;根据试验结果计算所得的风振系数值大于按规范公式估算值。这些结果不仅为结构的风荷载计算提供了依据,也有助于进一步认识该类异性烟囱结构的风荷载和风振特性。     

阴离子表面活性剂聚二硫二丙烷磺酸钠的合成

利用硫化钠与硫磺反应制备二硫化钠,然后将二硫化钠与1,3-丙磺酸内酯反应,合成了一种可作为电镀添加剂的阴离子表面活性剂——聚二硫二丙烷磺酸钠(SPS)。采用核磁共振氢谱对合成产物进行结构表征,确认了产物结构及产率。通过正交试验研究了产物产率与反应物配比、反应温度、溶剂加入量等因素之间的关系,找出了最优合成条件:第一步合成二硫化钠的反应中,硫化钠/硫磺物质的量比为1∶1.3,温度55℃,加水量18 mL;第二步合成SPS的反应中,1,3-丙磺酸内酯/硫化钠物质的量比为1.7∶1,温度40℃,溶剂量75 mL,产物的最高产率可达到95.8%。     

A Ready‐to‐Use Electrochemical Kit Design for the Diagnosis of Single Nucleotide Polymorphisms

In this study, for the first time a model electrochemical kit was constructed for the detection of a functional polymorphism in catechol‐O‐methyl transferase (COMT) gene which is important for diagnosis of neuropsychiatric disorders as Alzheimer disease. The disposable pencil graphite electrode (PGE) is designed as a “kit” and the probe DNA covered PGE can detect single nucleotide polymorphisms (SNPs) from real samples based on the guanine oxidation signal even after 5 months of kit preparation (150 days durability).The detection limit (S/N=3) of the biosensor was calculated as 1.18 pmol of synthetic target sequence and 6.09×10⁵ molecules of real samples in 30 min detection time.     

Design and Development of Oral Oil-in-Water Nanoemulsion Formulation Bearing Atorvastatin: In Vitro Assessment

The objective of the present investigation was to design a thermodynamically stable and dilutable nanoemulsion formulation of AT-Ca with minimum surfactant concentration that could improve its solubility as well as its oral bioavailability. The composition of optimized nanoemulsion formulation was Sefsol 218 and oleic acid (1:1) 10% w/w, as an oil phase, Tween-20 (19% w/w) as a surfactant, Carbitol (19% w/w) as a cosurfactant and distilled water (52% w/w) as an aqueous phase, containing 10 mg of AT. The optimized formulation showed higher% drug release (99.34%), lower droplet size (42.8 ± 0.42 nm) with low polydispersity index (0.237 ± 0.012), less viscosity (27.51 ± 1.01 cP) and infinite dilution capability. In vitro drug release from the nanoemulsion formulations was highly significant (p < 0.01) as compared to drug suspension.     

Flow Through Diffusion Cell Method: A Better Approach to Study Drug Release Behavior as Compared to Traditional Dissolution Test Method

Co‐polymeric hydrogels consisting of N‐vinyl‐2‐pyrrolidone (NVP) and acrylic acid (AAc) were synthesized and evaluated for release of a model drug, i.e., vitamin B₁₂. Release studies in simulated gastric fluid (pH 1.2) and intestinal fluid (pH 7.4), at 37°C, showed the hydrogels to be pH sensitive. An in vitro release study by ‘traditional dissolution test’ (TDT) showed that percent drug released from the hydrogel was nearly 8.6±2.1 and 83.2±4.8 in the media of pH 1.2 and 6.8, respectively. However, in order to incorporate in vivo GI conditions such as acidic pH and high water content in the stomach, low water content and the presence of a semi–solid mass in the large intestine, a new test model, called flow through diffusion cell (FTDC) was also used. The two approaches yielded almost different release profiles. The gels were characterized by thermogravimetric analysis and FTIR spectroscopy.     

A Tensile Strain Hardening Test Indicator of Environmental Stress Cracking Resistance

Environmental stress cracking resistance (ESCR) is an important indicator of performance for high density polyethylene (HDPE) in structural and polymer pipe applications. The commonly used test for determining ESCR of HDPE can be time consuming and rather imprecise. A tensile strain hardening test was recently proposed to offer a faster way to characterize ESCR of polyethylene. In this paper, a practical approach is adopted whereby the test is extended to room temperature and shown to relate reliably to the ESCR of HDPE. Several HDPE resins (including pipe‐grade resins) are analyzed at strain rates of 0.5 mm/min and 7 mm/min to compare the effect of strain rate. Comparisons between the conventional ESCR test method and the strain hardening test show that strain hardening can be used to rank ESCR of HDPE in a reliable fashion. In our study the more direct measure of “hardening stiffness” is used to compare resins instead of strain hardening modulus. Because no true stress‐strain measurement is needed, this is a much simpler test method than other methods previously suggested. In addition, the use of the natural drawing ratio (NDR) as ESCR ranking indicator is examined. Results show that NDR can also be employed as a strain rate‐independent indicator of ESCR of HDPE. The test proposed herein is practical, simple and precise, and hence a more reliable indicator of ESCR performance of HDPE.